Stanley Xu, PhD

Head of Biostatstics

Stan XuStanley Xu, PhD, is the Head of Biostatistics and a Senior Investigator at the Institute for Health Research. His research areas include longitudinal data analysis, analytic strategies in observational studies, count data analysis, missing data, outcome misclassification, and survival analysis.

Dr. Xu has completed doctoral training in both biochemistry and biometrics at the Beijing Agricultural University and the University of Colorado, Denver, respectively. He is responsible for developing analytic strategies for a variety of research problems in health outcomes and health services research and oversees the work of analytic staff within the IHR. He has contributed to several scientific fields including vaccine safety, cardiac outcomes, pharmacoepidemiology, health care utilization, and mental health.

Dr. Xu is an Adjunct Associate Professor in the Department of Biostatistics and Informatics at the University of Colorado School of Public Health and is a peer reviewer for a number of journals, including the Journal of Clinical Epidemiology and Vaccine.

Selected Research

  • Effectiveness of Disseminating Behavioral Activation using Peer Delivery for Pregnant Women with Depression

    The objective of this study is to use a three-phase structure to develop an activation peer delivery treatment model of web-based peer training and fidelity monitoring tools, to evaluate the feasibility, tolerability, acceptability, safety, and preliminary effectiveness of behavioral activation peer delivery within obstetric practice settings.
    Funder: National Institute of Mental Health

  • Pragmatic Trial of Population-based Programs to Prevent Suicide Attempt
    The goal of this project is to conduct a large, pragmatic trial to examine two population-based programs to prevent suicide attempt. Participants will be randomly assigned to continued usual care or usual care supplemented by one of the two prevention programs: an outreach and care management program (via secure messaging and telephone) including structured assessment linked to specific care pathways, or an online psycho-educational program focused on development of emotion regulation skills and prevention of suicidal behaviors, supported by coaching to promote engagement and adherence. The primary outcome will be suicide attempt (fatal or non-fatal) during 18 months following enrollment ? ascertained automatically from computerized records.
    Funder: National Institute of Mental Health
  • Reducing Residual Depressive Symptoms with Web-Based Mindful Mood
    The major goal of this project is to conduct a pragmatic randomized clinical trial of the Mindful Mood Balance (MMB) web-based program to evaluate its effectiveness in reducing residual depressive symptoms (RDS) in recurrently depressed patients.
    Funder: National Institute of Mental Health

  • Treatment Utilization before Suicide
    This project uses data from eight Mental Health Research Network affiliated health systems across the U.S. to investigate the association between other, non-psychiatric clinical factors, including medical diagnoses, medications, procedures, and types of visits and suicide risk.
    Funder: National Institute of Mental Health

  • Mental Health Research Network II
    To provide targeted expansion of the Mental Health Network to 1) develop capacity to perform trials involving pharmacotherapy, 2) develop procedures for deploying large-scale mental health IT interventions, and 3) conduct a signature project of a large population impact on an area of high priority to the field.
    Funder: National Institute of Mental Health

  • A Targeted Approach to Safer Use of Antipsychotics in Youth

    The goal of this project is to conduct a 3 phase study in which we (1) develop a sequenced treatment algorithm and workflow to facilitate safer antipsychotic prescribing in youth aged 5-17 years with non-psychotic disorders; (2) conduct a pilot trial of the algorithm and workflow versus usual care; and (3) conduct a large scale pragmatic effectiveness trial of the algorithm and workflow versus usual care in six health systems across the US.
    Funder: National Institute on Drug Abuse

  • Infrastructure Development Program in Patient-Centered Outcomes Research
    The aim of this sub-project is to examine the influence of individual, social, and neighborhood characteristics on the prevalence and treatment of depression in the city and county of Denver.
    Funder: Agency for Healthcare Research and Quality