doctor

Wendee Gozansky, MD, MPH

Wendee Gozansky, MD, MPH, is a clinician investigator at the Institute for Health Research as well as an Associate Professor of Medicine in the Division of Geriatrics at the University of Colorado Denver. Her research interests centered on improving the health of older adults are a natural extension of her work as an internist/geriatrician with the Kaiser Continuing Care Department. Her primary research focus on fracture prevention is exploring how to optimize use of bone mineral density testing, prevent falls, and improve adherence with drug therapy for osteoporosis. 

Institute for Health Research
10065 E. Harvard Ave Suite 300
Denver, CO 80231
wendolyn.s.gozansky@kp.org


CURRENT

Estrogen Deficiency and Mechanisms of Fat Accumulation
The aims of the proposed studies are to determine in postmenopausal women whether estrogen withdrawal causes: 1) a reduction in resting energy expenditure, increase in fat mass, and decrease in fat-free mass; and 2) dysregulation of hypothalamic-pituitary-adrenal axis activity.
Funder: National Institutes of Health/ National Institute on Aging

Prevalence and Predictors of DXA Utilization at Kaiser Permanente Colorado

The overall goal of this project is to acquire detailed information about DXA utilization at KPCO for both the primary prevention of fracture and management of those with an existing osteoporosis diagnosis.
Funder: Strategic Initiatives Committee, Institute for Health Research, Kaiser Permanente Colorado

COMPLETED

Cortisol Metabolism & Central Adiposity After Menopause
The major goal of this project is to determine whether estrogens act in peripheral tissues to decrease the net conversion of cortisone to cortisol in postmenopausal women.
Funder: National Institutes of Health/ National Institute on Aging Beeson Career Development Award in Aging
                       
Estradiol Regulation of In Vivo Adipose Tissue Glucocorticoid Metabolism
The global aim of these studies is to employ an experimental model to evaluate a potential biological mechanism of estradiol that could explain the perimenopausal loss of protection against abdominal adiposity.
Funder: National Institutes of Health/ National Institute on Aging

Biological Mechanisms of Arterial Stiffening With Age and Estrogen Deficiency

The aim of this project is to isolate the independent effects of age and estrogen deficiency on central artery stiffness in women.
Funder: National Institutes of Health/ National Institute on Aging

Acetaminophen and Impaired Musculoskeletal Adaptations to Exercise Training

The aim of this project is to determine whether taking acetaminophen before high-intensity exercise attenuates the usual increases in muscle and bone mass.
Funder: National Institutes of Health/ National Institute on Aging

The Beneficial Metabolic Effects of Fasting

The goal of this project is to determine whether intermittent fasting is more effective at inducing weight loss and improving insulin sensitivity when compared with a standard calorie restricted diet in obese women and men.
Funder: National Institutes of Health/ National Center for Complementary and Alternative Medicine

 

Bergouignan A, Gozansky WS, Barry DW, Leitner W, MacLean PS, Hill JO, Draznin B, Melanson EL. Increasing dietary fat elicits similar changes in fat oxidation and markers of muscle oxidative capacity in lean and obese humans. PLoS One 2012; 7(1): e30164  PMID: 22253914

Meditz AL, Moreau KL, Mawhinney S, Gozansky WS et al. CCR5 expression is elevated on endocervical CD4+ T-cells in healthy postmenopausal women. Journal of Acquired Immune Deficiency Syndromes 2012; 59(3) 221-2288. PMID: 22083068

Villalon KL, Gozansky WS, Van Pelt RE et al. A losing battle: weight regain does not restore weight loss-induced bone loss in postmenopausal women. Obesity (Silver Spring) 2011; 19(12): 2345-2350. PMID: 21852813

Day DS, Gozansky WS, Bell C, Kohrt WM. Acute sex hormone suppression reduces skeletal muscle sympathetic nerve activity. Clinical Autonomic Research 2011; 5(21): 339-345. PMID: 21638047

Jankowski CM, Gozansky WS, Van Pelt RE, Wolfe P, Schwartz RS, Kohrt WM. Oral dehydroepiandrosterone (DHEA) replacement in older adults: effects on central adiposity, glucose metabolism, and blood lipids. Clinical Endocrinology (Oxford) 2011; 4(75): 456-463. PMID: 21521341

Van Pelt RE, Jankowski CM, Gozansky WS, Wolfe P, Schwartz RS, Kohrt WM. Sex differences in the association of thigh fat and metabolic risk in older adults. Obesity (Silver Spring) 2011; 19(2):422-428. PMID: 20559300

Melanson EL, Gozansky WS, Barry DW, Maclean PS, Grunwald GK, Hill JO. When energy balance is maintained, exercise does not induce negative fat balance in lean sedentary, obese sedentary, or lean endurance-trained individuals. Journal of Applied Physiology 2009; 107(6):1847-1856. PMID: 19833807

Jankowski CM, Gozansky WS, Kittelson JM, Van Pelt RE, Schwartz RS, Kohrt WM. Increases in bone mineral density in response to oral dehydroepiandrosterone replacement in older adults appear to be mediated by serum estrogens. Journal of Clinical Endocrinology & Metabolism 2008; 93(12):4767-4773. PMID: 18812486

Jankowski CM, Gozansky WS, Van Pelt RE et al. Relative contributions of adiposity and muscularity to physical function in community-dwelling older adults. Obesity (Silver Spring) 2008; 16(5):1039-1044. PMID: 18292753

Jankowski CM, Gozansky WS, Schwartz RS et al. Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial. Journal of Clinical Endocrinology & Metabolism 2006; 91(8):2986-2993. PMID: 16735495

Van Pelt RE, Gozansky WS, Hickner RC, Schwartz RS, Kohrt WM. Acute modulation of adipose tissue lipolysis by intravenous estrogens. Obesity (Silver Spring) 2006; 14(12):2163-2172. PMID: 17189542

Fischer SM, Gozansky WS, Sauaia A, Min SJ, Kutner JS, Kramer A. A practical tool to identify patients who may benefit from a palliative approach: the CARING criteria. Journal of Pain and Symptom Management 2006; 31(4):285-292. PMID: 16632076

Van Pelt RE, Jankowski CM, Gozansky WS, Schwartz RS, Kohrt WM. Lower-body adiposity and metabolic protection in postmenopausal women. Journal of Clinical Endocrinology & Metabolism 2005; 90(8):4573-4578. PMID: 15886255

Gozansky WS, Lynn JS, Laudenslager ML, Kohrt WM. Salivary cortisol determined by enzyme immunoassay is preferable to serum total cortisol for assessment of dynamic hypothalamic--pituitary--adrenal axis activity. Clinical Endocrinology (Oxford) 2005; 63(3):336-341. PMID: 16117823

Gozansky WS, Van Pelt RE, Jankowski CM, Schwartz RS, Kohrt WM. Protection of bone mass by estrogens and raloxifene during exercise-induced weight Loss. Journal of Clinical Endocrinology & Metabolism 2005; 90(1):52-59. PMID: 15494466

Day DS, Gozansky WS, Van Pelt RE, Schwartz RS, Kohrt WM. Sex hormone suppression reduces resting energy expenditure and {beta}-adrenergic support of resting energy expenditure. Journal of Clinical Endocrinology & Metabolism 2005; 90(6): 3312-3317. PMID: 15741268

Nowbar S, Burkart KM, Gonzales R et al. Obesity-associated hypoventilation in hospitalized patients: prevalence, effects, and outcome. American Journal of Medicine 2004; 116(1):1-7. PMID: 14706658

Jankowski CM, Sonko BJ, Gozansky WS, Kohrt WM. Deuterium dilution: the time course of 2H enrichment in saliva, urine, and serum. Clinical Chemistry 2004; 50(9):1699-1701. PMID: 15331513

Jankowski CM, Ben-Ezra V, Gozansky WS, Scheaffer SE. Effects of oral contraceptives on glucoregulatory responses to exercise. Metabolism 2004; 53(3):348-352. PMID: 15015148

Fischer SM, Gozansky WS, Kutner JS, Chomiak A, Kramer A. Palliative care education: an intervention to improve medical residents' knowledge and attitudes. Journal of Palliative Medicine 2003;6(3): 391-399. PMID: 14509484

Kohrt WM, Van Pelt RE, Gozansky WS. Effects of estrogen replacement on metabolic factors that influence physical performance in female hypogonadism. Journal of Endocrinological Investigation 2003; 26(9):902-910. PMID: 14964444

Page RL, Gozansky WS, Ruscin JM. Possible heart failure exacerbation associated with rosiglitazone: case report and literature review. Pharmacotherapy 2003; 23(7):945-954. PMID: 12885108

Van Pelt RE, Gozansky WS, Schwartz RS, Kohrt WM. Intravenous estrogens increase insulin clearance and action in postmenopausal women. America Journal of Physiology, Endocrinology, & Metabolism 2003; 285(2):E311-E317. PMID: 12684221

Whitney CG, Plikaytis BD, Gozansky WS, Wenger JD, Schuchat A. Prevention practices for perinatal group B streptococcal disease: a multi-state surveillance analysis. Neonatal Group B Streptococcal Disease Study Group. Obstetrics & Gynecology 1997; 89(1):28-32. PMID: 8990432