Stan Xu, PhD
Stanley Xu, PhD, is the Head of Biostatistics and an Investigator at the Institute for Health Research. He is an Adjunct Associate Professor in the Department of Biostatistics and Informatics at the School of Public Health at the University of Colorado. He is responsible for developing analytic strategies for a variety of research problems in health outcomes and health services research and overseeing work of analytic staff. His research areas include longitudinal data analysis, count data analysis, missing data and survival analysis.
Institute for Health Research
10065 E. Harvard Ave Suite 300
Denver, CO 80231
stan.xu @ kp.org
Vaccine Safety Datalink: Comprehensive Link Data Collection of Medical Events and Immunization
To investigate the safety of vaccines in children and adults in a large national cohort
Funder: Centers for Disease Control and Prevention/ America’s Health Insurance Plans
Telecommunications Enhanced Asthma Management (TEAM)
This project is a practical, randomized clinical trial to test the impact of a health communication intervention designed to improve inhaled asthma controller medication adherence in 3-12 year old children with asthma through parental contact.
Funder: National Heart Lung and Blood Institute
Colorado Clinical and Translational Sciences Institute (CCTSI), the Biostatistics, Epidemiology, and Research Design (BERD) Program
Goals of the Biostatistics, Epidemiology, and Research Design (BERD) Program are 1) Develop and maintain the BERD leadership and biostatistics consortium; 2) Provide consultation/collaboration in biostatistics, epidemiology, and study design; 3) Provide training and mentorship in biostatistics and epidemiology; 4) To advance biostatistical and epidemiological methods for translational research.
Role: Biostatistician/Steering committee of BERD core
Funder: National Institutes of Health/ National Center for Research Resources
Longitudinal Studies of Implantable Cardiac Defibrillators (ICDs)
The overall objective of this modified study is to gain understanding of the patterns and appropriateness of device therapies among patients undergoing ICD implantation for primary prevention of sudden cardiac death.
Role: Lead Biostatistician
Funder: National Institutes of Health/ Agency for Healthcare Research and Quality
Mechanisms of Physical Activity and Behavior Change
This project uses an individually-tailored physical activity intervention delivered through efficient and scalable interactive technologies directed at patients who have been referred for a treadmill cardiovascular stress test.
Funder: National Institutes of Health/ National Institute of Diabetes and Digestive and Kidney Diseases
Center for Rural Mental Health Services Research
The objective of the center is to develop and disseminate scientific knowledge that can be readily applied to improve the use, quality and outcomes of mental health care provided to rural populations. The proposed research portfolio consists of a closely coordinated set of quantitative studies: (1) to identify at-risk areas within rural American to target for depression quality improvement adoption, (2) to determine whether and why existing care models differentially improve treatment in rural and urban patient populations, (3) to explore promising hospitalization prevention strategies which have the potential to provide more funding for outpatient specialty care, and (4) to identify potential payers who economically benefit with the adoption of depression quality improvement programs
Funder: Health Services Research Administration, Office of Rural Health Policy
Diabetes and Drug-Associated Hyperkalemia: Effect of Laboratory Monitoring
This study assesses associations between receipt and timing of potassium monitoring and the occurrence of
hyperkalemia-associated adverse events in patients with diabetes who are prescribed angiotensin converting
enzyme inhibitors, angiotensin receptor blockers and/or aldosterone receptor antagonists.
Role: Lead Biostatistician
Funder: National Institute of Diabetes and Digestive and Kidney Diseases
Longitudinal Outcomes following Drug Eluting Stent Implantation
This project will be a retrospective cohort study of ~10,000 patients undergoing drug eluting stent placement in 3 large healthcare organizations and determine the relationship between anti-platelet therapy with clopidogrel and the occurrence of adverse outcomes following DES implantation.
Role: Lead Biostatistician
Funder: Agency for Healthcare Research and Quality/ Centers for Education and Research in Therapeutics
Ray CE Jr, Battaglia C, Libby AM, Prochazka A, Xu S, Funaki, B. Interventional radiologic treatment of hepatocellular carcinoma-a cost analysis from the payer perspective. Journal of Vascular and Interventional Radiology 2012; 23(3): 306-314. PMID: 22277271
Raebel MA, Ellis JL, Carroll NM et al. Characteristics of patients with primary non-adherence to medications for hypertension, diabetes and lipid disorders. Journal of General Internal Medicine 2012; 27(1):57-64. PMID: 21879374
Glanz JM, Newcomer SR, Hambidge SJ et al. Safety of trivalent inactivated influenza vaccine in children aged 24 to 59 months in the vaccine safety datalink. Archives of Pediatric & Adolescent Medicine 2011; 165(8):749-755. PMID: 21810637
Xu S, Shetterly S, Powers D, Raebel MA, Tsai TT, Ho PM, Magid D. Extension of Kaplan-Meier methods in observational studies with time-varying treatment. Value Health 2012; 15(1): 167-174. PMID: 22264985
Xu S, Rost K, Dong F and Dickinson M. Stakeholder Benefit from Depression Disease Management: Differences by Rurality? Journal of Behavioral Health Services & Research 2011; 38: 114-121. PMID: 20052619
Estabrooks PA, Glasgow RE, Xu S, et al. Building a multiple modality, theory-based physical activity intervention: The development of CardiACTION! Psychology of Sport and Exercise 2011; 12(1): 46-53. PMID: 22473308
Rost K, Hsieh YP, Xu S, Menachemi N, Young AS. Potential disparities in the management of schizophrenia in the United States. Psychiatric Services 2011; 2(6):613-8. PMID: 21632729
Rost K, Hsieh YP, Xu S, Harman J. Gender differences in hospitalization after emergency room visits for depressive symptoms. Journal of Womens Health (Larchmt) 2011; 20(5):719-24. PMID: 21417934
Fortney JC, Harman JS, Xu S, and Dong F. The Association Between Rural Residence and the Use, Type, and Quality of Depression Care. Journal of Rural Health 2011; 26(3):205-13. PMID: 20633088
Xu S, Zhang L, Nelson JC, Zeng C, Mullooly J, McClure D, Glanz J. Identifying optimal risk windows for self-controlled case series studies of vaccine safety. Statistics in Medicine 2011; 30(7): 742-752. PMID: 21394750
Tsai TT, Ho, PM, Xu S, Powers JD, Carroll NM, Shetterly SM, et al. Increased risk of bleeding in patients on clopidogrel therapy after drug-eluting stents implantation: insights from the HMO research network- stent registry (HMORN-stent). Circulation: Cardiovascular Interventions 2010; 3(3):230-5. PMID: 20442361
Xu S, Gargiullo P, Mullooly J, McClure D, Hambidge S and Glanz J. Fitting parametric and semi-parametric conditional Poisson regression models with Cox’s partial likelihood in self-controlled case series and matched cohort studies. Journal of Data Science 2010; 8: 349-360.
Xu S, Ross C, Raebel M, Shetterly S, Blanchette C, Smith D. Use of Stabilized Inverse Propensity Scores as Weights to Directly Estimate Relative Risk and Its Confidence Intervals. Value in Health 2010; 13:273-277. PMID: 19912596
Raebel MA, Smith ML, Saylor G, Wright LA, Cheetham C, Blanchette CM, Xu S. The Positive Predictive Value of a Hyperkalemia Diagnosis in Automated Health Care Data. Pharmacoepidemiology and Drug Safety 2010; 19(11):1204-8. PMID: 20878650
Raebel MA, Ross C, Xu S, Roblin DW, Cheetham C; Blanchette CM, Saylor G, Smith DH. Diabetes and Drug-Associated Hyperkalemia: Effect of Serum Potassium Monitoring. Journal of General Internal Medicine 2010; 25(4):326-33. PMID: 20087674
Raebel MA, Ross C, Cheetham C, Petersen H, Saylor G, Smith DH, Wright LA, Roblin DW, Xu S. Increasingly Restrictive Definitions of Hyperkalemia Outcomes in a Database Study: Effect on Incidence Estimates. Pharmacoepidemiology and Drug Safety 2010; 19(1):19-25. PMID: 19937982
Estabrooks PA, Shoup J, Gattshall M, Dandamudi P, Shetterly S, Xu S. Automated Telephone Counseling for Parents of Overweight Children: A Randomized Controlled Trial. American Journal of Preventive Medicine 2009; 36(1):35-42. PMID: 19095163
John CF, Xu S, Dong F. Community-Level Correlates of Hospitalizations for Persons with Schizophrenia. Psychiatric Services 2009; 60:772-778. PMID: 19487346
Glanz J, France E, Xu S, Hayes T, Hambidge S. A Population-Based, Multisite Cohort Study of the Predictors of Chronic Idiopathic Thrombocytopenic Purpura in Children. Pediatrics 2008; 121(3): e506 - e512. PMID: 18310170
France E, , Glanz J, Xu S, Hambidge S, et al. Risk of Immune Thrombocytopenic Purpura After Measles-Mumps-Rubella Immunization in Children. Pediatrics 2008; 121(3):687 -692. PMID: 18310189
McClure D, Glanz J, Xu S, et al. Comparison of epidemiologic methods for active surveillance of vaccine safety. Vaccine 2008; 26: 3341-5. PMID: 18462849
Albright K, Fortney J, Adams S, Dong F, Xu S. The Role of Social Support and Stressful Life Events in the Effectiveness of Collaborative Care for Depression: A Rural-Urban Comparison. Journal of Rural Mental Health 2008; 31(4): 6-27.
Xu S, Grunwald G, Jones R. A Simulation Study Comparing Likelihood and Nonlikelihood Approaches in Analyzing Overdispersed Count Data. American Statistical Association 2008 Proceedings of the Section on Biometrics.
Xu S, Jones R, and Grunwald G. Analysis of Longitudinal Count Data with Serial Correlation. Biometrical Journal 2007; 49(3): 416 - 428. PMID: 17623346
Graham A, Goss C, Xu S, Magid DJ, Diguiseppi C. Effect of using different modes to administer the AUDIT-C on identification of hazardous drinking and acquiescence to trial participation among injured patients. Alcohol and Alcoholism 2007; 42(5): 423-429. PMID: 17341515
Fortney J, Rushton G, Wood S, Zhang l, Xu S, Dong F, Rost K. Community-Level Risk Factors for Depression Hospitalizations. Administration and Policy in Mental Health 2007; 34(4):343-352. PMID: 17294123
Sills MR, Shetterly S, Xu S, Magid D, Kempe A. The Association Between Parental Depression and Children’s Healthcare Utilization. Pediatrics 2007; 119(4); e829-836. PMID: 17403826
Rost K, Adams S, Xu S, Dong F. Rural-urban differences in hospitalization rates of primary care patients with depression. Psychiatric Services 2007; 58(4):503-8. PMID: 17412852
France E, Smith-Ray R, McClure D, Hambidge S, Xu S, et al. Impact of Influenza Vaccination During Pregnancy on the Incidence of Acute Respiratory Illness Visits Among Infants. Archives of Pediatric & Adolescent Medicine 2006; 160:1277-1283. PMID: 17146026
Hambidge S, Glanz J, France E, McClure D, Xu S; et al. Safety of Trivalent Inactivated Influenza Vaccine in Children 6 to 23 Months Old. Journal of the American Medical Association 2006; 296 (16): 1990-1997. PMID: 17062862
Glanz J, McClure D Xu S., et al. Comparison of four study designs for evaluating vaccine safety: Retrospective cohort, case-control, risk-interval and self-controlled case series. Journal of Clinical Epidemiology 2006; 59: 808–818. PMID: 16828674
Jones R, Xu S, and Grunwald G. Markov Models for Binary Longitudinal Data with Serial Correlation. Biometrical Journal 2006; 48: 411-419. PMID: 16845905
Adams AJ, Xu S, Dong F, Fortney J. Differential Effectiveness of Enhanced Depression Treatment for Rural and Urban Primary Care Patients. The Journal of Rural Health 2006; 22(4), 343-350. DOI: 10.1111/j.1748-0361.2006.00056.x
DiGuiseppi CG, Goss C, Xu S, Magid D, Graham A. Telephone screening for problem drinking among injured patients seen in acute care clinics: feasibility study. Alcohol and Alcoholism 2006; 41(4):438-445. PMID: 16679344
Estabrooks PA, Nelson CC, Xu S, King D, Bayliss EA, Gaglio B, Nutting PA, Glasgow RE. The Frequency and Behavioral Outcomes of Goal Choices in the Self-management of Diabetes. The Diabetes Educator 2006; 31(3): 391-400. PMID: 15919639
Price DW, Xu S, McClure D. Effect of CME on Primary Care and OB/GYN Treatment of Breast Masses. Journal of Continuing Education in the Health Professions 2005; 35(4): 240-247. PMID: 16365900
Lin ND, Kleinman K, Chan KA, Yu XJ, France EK, Xu S, Wei F, et al. Impact of the introduction of Pneumococcal Conjugate Vaccine on Immunization Coverage among Infants. BMC Pediatrics 2005; 5:43. PMID: 16313673
France E, Glanz J, Xu S, Davis R, et al. Safety of the trivalent inactivated influenza vaccine among children: A population-based study. Archives of Pediatric & Adolescent Medicine 2004; 158(11):1031-36. PMID: 15520339
Raebel MA, Malone DC, Conner DA, Xu S, Porter JA, Lanty FA. Health services use and health care costs of obese and non-obese individuals. Archives of Internal Medicine 2004; 164: 2135-40. PMID: 15505127
Price DW, Swaney RE, Xu S, Goodspeed JR, Steiner JF. Care of common medical conditions in a managed care program for uninsured adults. The Permanente Journal 2002; 7:27-35.
Daley MF, Steiner JF, Brayden RM, Xu S, Morrison S, Kempe A. Immunization registry-based recall for a new vaccine. Ambulatory Pediatrics 2002; 2(6):438-443. PMID: 12437389
Xu, S. Sensitivity and specificity in testing for diseases. Contingencies 2000; January/February: 56-58.
Nieto Y, Xu S, Cagnoni PJ, Matthes S, Shpall EJ, Bearman SI, Murphy J, Jones RB. Non-predictable pharmacokinetic behavior of high-dose cyclophosphamide, in combination with cicplatin and BCNU. Clinical Cancer Research 1999; 5(4):747-751. PMID: 10213208
Nieto Y, Cagnoni PJ, Xu S, Jones RB, Shpall EJ, Murphy J, Ross M, Bearman SI. A predictive model for relapse in high-risk primary breast cancer patients treated with high dose chemotherapy and autologous stem-cell transplant. Clinical Cancer Research 1999; 5(4): 3425-3431. PMID: 10589754
Xu S, Shannon K, Voelker DR, Mason RJ. KGF increases SP-A and SP-D mRNA levels and secretion in cultured rat alveolar type II cells. American Journal of Respiratory Cell and Molecular Biology 1998; 18(2): 168-178. PMID: 9476903
Xu S, Shannon K, Voelker DR, Mason RJ. Culture system for studying secretion of surfactant proteins by rat alveolar type II cells. Molecular Biology of the Cell1995; 6: 187a.