Current Research Projects by Investigator



Elizabeth Bayliss Elizabeth A. Bayliss, MD, MSPH

Health outcomes for complex patients: Continuity of care and patient perspectives.
Assess health outcomes in complex patients as a function of multiple different subjective factors such mediated by different types of continuity of care. 
Funder: Agency for Healthcare Research and Quality 

Scalable PArtnering Network for CER: Across Lifespan, Conditions, and Settings. 
This project will develop a distributed research network, which will create linkages across health care systems to provide access to current patient-level data that supports a dynamic foundation for conducting observational investigations and improves recruitment for interventional research. Over time, the network will expand to facilitate study of broad spectrums of treatments for multiple health conditions in complex and diverse populations across multiple types of health delivery systems.
Funder: Agency for Healthcare Research and Quality 

Determining Processes of Cardiovascular Care Relevant to Complex Patients.

We will study an historical cohort of adults with an initial diagnosis of cancer during the period 1999 to 2007. We will a) assess the attainment of goals for specific components of primary, secondary, and ‘tertiary’ prevention of coronary heart disease as a function of cancer prognosis, overall morbidity and the interaction between them, and b) assess the comparative effectiveness of these coronary heart disease prevention interventions on a composite coronary heart disease outcome.
Funder: Agency for Healthcare Research and Quality 

Investigation of patient-reported pain outcomes to inform diabetic peripheral neuropathy treatment and research. 
This project is exploring strategies for validating and collecting patient-reported pain outcomes to facilitate comparative effectiveness and safety studies related to painful DPN in diverse patient populations.
Funder: Kaiser Permanente National

HMO Research Network CERT III Anti –TNF.
There are two broad aims for CERT3: 1) Enhance the collective ability of the HMO Research Network and other collaborating health plans to advance therapeutics knowledge by leveraging unique data sources within a very large, generalizable population. 2) Develop and implement new multi-faceted methods for disseminating and promoting best therapeutic practices. 
Funder: Agency for Healthcare Research and Quality 

Evaluation of care needs of KPCO members with regard to the Affordable Care Act.

Funder: Kaiser Permanente Colorado


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Arne Beck Arne L. Beck, PhD

Mental Health Research Network: A Population Based Approach to Transform Research
The major goal of this project is to develop a Mental Health Research Network (MHRN) including nine established public-domain research centers based in integrated not-for-profit health systems, and to support development of a core infrastructure for collaborative effectiveness research in mental health and completion of 4 research projects that leverage that infrastructure in specific clinical areas.  
Funder: National Institute of Mental Health

Mental Health Disorders and Medication Adherence and Outcomes in Hypertension, Atrial Fibrillation, and Venous Thromboembolism within the CVRN
The major goal of this project is to examine the relation between three prevalent mental health disorders (depression, anxiety disorders, and ADHD), their associated therapies, and outcomes for hypertension, atrial fibrillation and venous thromboembolic disease within the NHLBI-sponsored Cardiovascular Research Network (CVRN).
Funder: National Heart Lung and Blood Institute/ National Institute of Mental Health

Increasing Access to Relapse Prophylaxis in MDD with Web-Based MBCT (eMBCT)
 
The major goal of this project is to develop and test a web-based application of mindfulness based cognitive therapy for depression relapse prevention.
Funder: National Institute of Mental Health

Evaluation of Value-Based Health Plan Design
The major goal of this project is to evaluate the impact of a value based health plan design implemented in the Group Health Cooperative employee population using KPCO as a comparison site.
Funder: Agency for Healthcare Research and Quality


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Matthew Daley Matthew F. Daley, MD

Risk Factors for Nevus Development in Children
The broad, overarching hypothesis of this study is that the interaction of sun exposure and genetics is critical for nevus formation.  This will be addressed by examining the inter-relationships among the three major factors that are known to influence nevus development-UV exposure, sun protection behavior, and genetics.
Role: Co-Investigator
Funder: National Cancer Institute

Childhood Hypertension and Obesity:  Diagnosis, Care, and Costs

Our objective in this project is to assess current patterns in the diagnosis and management of children with hypertension and obesity.
Role: Co-Investigator
Funder: National Heart Lung and Blood Institute

Scalable PArtnering Network for CER: Across Lifespan, Conditions and Settings

The objective is to develop a distributed research network that is interoperable across a range of health care systems and sites, incorporating large and diverse patient populations.  The network infrastructure will have the capability to conduct large comparative effectiveness research (CER) studies using data collected on patient-reported outcomes collected at the point of care and real-time data collection.
Role: Principal Investigator
Funder: Agency for Healthcare Research and Quality

Adolescent Vaccination in the Medical Home: Established and Innovative Strategies

The purpose is to design evidence-based and innovative strategies to encourage adolescents to receive vaccines and then to implement those strategies with the goal of making the strategies sustainable.
Role: Co-Investigator
Funder: Centers for Disease Control and Prevention/ National Center for Immunization and Respiratory Diseases

An Evaluation of an Interactive Social Media Website for Parents who are Concerned about Immunizing Their Children

The purpose of this project is to develop and evaluate an interactive, social media website for parents who are concerned about vaccinating their children.  The site will be moderated by physicians and vaccine researchers in this pilot study.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality

Vaccine Safety Datalink (VSD) Comprehensive Link Data Collection of Medical Events and Immunization
The major goal of this project is to evaluate the safety of currently licensed vaccines in the U.S. To accomplish this goal, we provide electronic clinical data to the weekly dynamic data files and lead specific vaccine safety studies within the VSD.
Role: Co-Investigator
Funder: Centers for Disease Control and Prevention/ America’s Health Insurance Plans


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Heather Spencer Feigelson Heather Spencer Feigelson, PhD, MPH

Infrastructure Support to Develop the Center for Excellence in Cancer and Genomics (C-Gen)
This project aims to establish a Center for Excellence in Cancer and Genomics (C-Gen) at KPCO.  C-Gen will bring considerable expertise in cancer and genomics into an organized structure that will allow for efficiency, enhanced collaboration and rapid growth in this content area.
Role: Co-Director
Funder: Kaiser Permanente Colorado Strategic initiatives Committee

Statins & Lymphoid Malignancy Risk in a Large Multi-site Population-based Cohort
The goal of this study is to investigate whether statins, drugs widely used to lower cholesterol and prevent heart attack and stroke, may also benefit patients who are beingtreated for prostate cancer. We will analyze more than 5,000 patients' electronicmedical records from the Kaiser Permanente Northwest health care system and the Veterans Administration; these two systems have extensive electronic datathat will allow us to examine prostate cancer cases that were diagnosed after statin use became common. Our results could lead to clinical trials and the eventual development of effective and safe therapy that helps prevent and reduce prostate cancer recurrence after initial therapy. Because statins are already in use, new findings about their role in cancer could translate quickly into practice.
Role: Co-Investigator
Funder: National Cancer Institute

CESR Statins and Prostate Cancer
The goal of this study is to investigate whether statins, drugs widely used to lower cholesterol and prevent heart attack and stroke, may also benefit patients who are beingtreated for prostate cancer. We will analyze more than 5,000 patients' electronicmedical records from the Kaiser Permanente Northwest health care system and the Veterans Administration; these two systems have extensive electronic datathat will allow us to examine prostate cancer cases that were diagnosed after statin use became common. Our results could lead to clinical trials and the eventual development of effective and safe therapy that helps prevent and reduce prostate cancer recurrence after initial therapy. Because statins are already in use, new findings about their role in cancer could translate quickly into practice.
Role: Site Investigator
Funder: CESR

Treatment Patterns and Recurrence of DCIS across Multiple CESR Sites
The main goal of this project is to describe treatment patterns for DCIS over time, across KP regions, tumor characteristics, patient age and comorbidity status; estimate breast cancer recurrence and second breast cancer (both ipsilateral and contralateral) among women with DCIS by treatment type; describe the use of pre-operative MRI and sentinel lymph node biopsy (SLNB) over time, by region, tumor characteristics and patient age and determine whether SLNB or pre-operative MRI are associated with increased use of mastectomy.
Role: Principal Investigator
Funder: CESR

Lung Nodule
The goal of this study is to develop biomarkers that are useful in informing clinical management of CT detected lung nodules of indeterminate etiology. We will collect risk factor information along with a variety of biospecimens, including sputum, blood, and tissue specimens when available, from KPCO members with lung nodules. We hope to identify biomarkers measurable in non-invasively obtained specimens that can discriminate between benign and malignant lung nodules.
Role: Principal Investigator
Funder: University of Colorado Cancer Center

BRANCH II: Pilot
The Breast and Colon Health Study (BRanCH) phase II is a pilot study designed to test the feasibility of (1) collection urine and stool samples from women recently diagnosed with breast cancer, and (2) re-sample women who previously agreed to provide such samples.
Role: Principal Investigator
Funder: National Cancer Institute


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Jason Glanz Jason Glanz, PhD

Vaccine Refusal: Clinical Impact and Parental Attitudes
Role: Principal Investigator
Funder: National Institute of Allergy and Infectious Disease

Vaccine Safety Datalink: Comprehensive Link Data Collection of Medical Events and Immunizatio
n
To investigate the safety of vaccines in children and adults in a large national cohort.
Role: Co-Principal Investigator
Funder: Centers for Disease Control and Prevention/ America’s Health Insurance Plans

Scalable PArtnering Network for CER: Across Lifespan, Conditions and Settings
The objective is to develop a distributed research network that is interoperable across a range of health care systems and sites, incorporating large and diverse patient populations.  The network infrastructure will have the capability to conduct large comparative effectiveness research (CER) studies using data collected on patient-reported outcomes collected at the point of care and real-time data collection.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality

An Evaluation of an Interactive Social Media Website for Parents who are Concerned about Immunizing Their Children
Conduct a formative and summative evaluation of a social media website design to allay parents concerns about vaccinations, and to use the data collected in the evaluation to design a large, randomized intervention trial to evaluate the efficacy of the website in ambulatory care setting
Role: Principal Investigator
Funder: Agency for Healthcare Research and Quality


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Wendee Gozansky Wendee Gozansky, MD, MPH

Estrogen Deficiency and Mechanisms of Fat Accumulation
The aims of the proposed studies are to determine in postmenopausal women whether estrogen withdrawal causes: 1) a reduction in resting energy expenditure, increase in fat mass, and decrease in fat-free mass; and 2) dysregulation of hypothalamic-pituitary-adrenal axis activity.
Role: Co-Investigator
Funder: National Institutes of Health/ National Institute on Aging

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David Magid David J. Magid, MD, MPH

HIMO: Cardiovascular Research Network (CVRN) Core
The aims of this study are to create a network to support cardiovascular research, through development of data standardization, infrastructure components, and organizational structure, as required to support large-scale, population-based studies.
Role: Co-Principal Investigator
Funder: National Heart Lung and Blood Institute                 

Telecommunications Enhanced Asthma Management (Breathe-Well Study)
This project is a practical, randomized clinical trial to test the impact of a health communication intervention designed to improve inhaled asthma controller medication adherence in 3-12 year old children with asthma through parental contact.
Role: Co-Investigator
Funder: National Heart Lung and Blood Institute                 

Personalized Physician Learning Intervention to Improve Hypertension Control

This project assesses the impact of two PPL interventions that differ in how they identify patterns of physician decision making in HT care.
Role: Site Principal Investigator
Funder: National Heart Lung and Blood Institute                 

Management and Outcomes of Heart Failure with Preserved Systolic Function
The objective is to study adults with heart failure and preserved left ventricular systolic function.
Role: Site Principal Investigator
Funder: National Heart Lung and Blood Institute                             

Development of a Cardiovascular Surveillance System in the CVRN

This project will establish a surveillance system for cardiovascular disease in approximately 11 million health maintenance organization (HMO) members.
Role: Site Principal Investigator
Funder: Agency for Healthcare Research and Quality          

The Association Between Providers' Ethnic/Racial Biases and Hypertension Control

This project is designed to fill that gap by measuring providers' implicit (unconscious) and explicit (conscious) biases toward African Americans and Latinos, and examining the degree to which those biases are associated with disparities in hypertensive patients' perceptions, disease management, and health outcomes.
Role: Site Principal Investigator
Funder: National Heart Lung and Blood Institute                 

Childhood Hypertension and Obesity:  Diagnosis, Care, and Costs

This project will address these critical gaps in knowledge using detailed clinical data extracted through Electronic Medical Records (EMR) at large medical groups in Colorado, Minnesota, and California.
Role: Site Principal Investigator
Funder: National Heart Lung and Blood Institute                 

DEcIDE Distributed Research Network – Phase II (DRN2)
This project is designed to provide infrastructure to support studies of comparative effectiveness.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality          

Longitudinal Studies of Implantable Cardioverter Defibrillators for Primary Prevention

The aim of this study to identify the patterns and determinants of complications, morbidity, mortality, and costs of ICDs in a large, community-based population.
Role: Principal Investigator
Funder: Agency for Healthcare Research and Quality          

Cardiovascular Research Network (CVRN)- Mental Health Supplement
The aim of this study is to evaluate cardiovascular risks in patients with mental health.
Role: Co-Investigator
Funder: The National Institute of Mental Health/ National Heart Lung and Blood Institute 

Effectiveness of Medical Therapy, Endovascular Therapy and Surgery for Peripheral Artery Disease
This study is designed to assemble a clinical registry of PAD patients undergoing lower extremity revascularization (surgery or endovascular) in both Kaiser Colorado and Kaiser Northern California. 
Role: Principal Investigator
Funder: Agency for Healthcare Research and Quality          

Observational Study for Asthma Control & Outcomes (OSACO)
This economic and health services research is a prospective survey, spirometry, and administrative data analysis of asthma patients in Kaiser Permanente Colorado (KPCO). 
Role: Principal Investigator Funder: Amgen


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Ted Palen Ted Palen, PhD, MD, MSPH

Guide to Identifying and Remediating Unintended Consequences of Implementing Health IT
Subcontracted to RAND
Role: Principal Investigator
Funder: Agency for Healthcare Research and Quality


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David Price David W. Price, MD

Mental Health Research Network: A Population Based Approach to Transform Research
The major goal of this project is to develop a Mental Health Research Network (MHRN) including nine established public-domain research centers based in integrated not-for-profit health systems, and to support development of a core infrastructure for collaborative effectiveness research in mental health and completion of 4 research projects that leverage that infrastructure in specific clinical areas. 
Funder: The National Institute of Mental Health            

Diabetes Prevention Program Outcomes Study

Role: Site Co-Principal Investigator
Funder: National Institutes of Health/ National Institute of Diabetes and Digestive and Kidney Diseases


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Marsha Raebel Marsha A. Raebel, PharmD, BCPS, FCCP

Efforts to Develop the Sentinel Initiative
The Sentinel System will be a national electronic active surveillance system that greatly enhances the ability of the FDA to track the safety of FDA-regulated drugs, biologics, and medical devices. The pilot program, known as Mini-Sentinel, is the Agency’s first step towards building this nationwide rapid-response electronic safety surveillance system.
Role: KP Lead Investigator
Funder: United States Food and Drug Administration

Multi-Institutional Consortium for CER in Diabetes Treatment and Prevention (PROSPECT; SUPREME-DM)

In this “next-generation” multi-system registry we are proposing, it is intended to serve as a resource for a wide range of CER on both individual therapies and system-level interventions, and specifically to support examination of heterogeneity in effectiveness across patient subgroups defined by race/ethnicity, age, co-morbidities, or psychosocial variables, and across systems.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality

Scalable PArtnering Network for CER: Across Lifespan, Conditions and Settings (SPAN)

The objective is to develop a distributed research network that is interoperable across a range of health care systems and sites, incorporating large and diverse patient populations.  The network infrastructure will have the capability to conduct large comparative effectiveness research (CER) studies using data collected on patient-reported outcomes collected at the point of care and real-time data collection.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality

Medication Use in Pregnancy and Birth Outcomes Program (MEPREP): Systemic sulfonamide use during pregnancy and the risk of selected congenital anomalies

In this project we will measure the association between exposure to sulfonamides during pregnancy and congenital abnormalities in the offspring, maintain all data, data linkages, standardized datasets, and organizational structure, created in the MEPREP pilot program, and evaluate the efficiency of conducting in-depth epidemiological studies using the data, data linkages, standardized datasets, and organizational structure created by the MEPREP pilot program.
Role: Site Principal Investigator
Funder: United States Food and Drug Administration

Mental Health Research Network: A Population Based Approach to Transform Research

The major goal of this project is to develop a Mental Health Research Network (MHRN) including nine established public-domain research centers based in integrated not-for-profit health systems, and to support development of a core infrastructure for collaborative effectiveness research in mental health and completion of 4 research projects that leverage that infrastructure in specific clinical areas.
Role: Co-Invetigator
Funder: The National Institute of Mental Health

The Developing Evidence to Inform Decisions about Effectiveness-2 (DEcIDE-2) Network

The DEcIDE-2 network supports AHRQ's response to the Medicare Modernization Act's mandates for comparative effectiveness and safety research. The Network develops scientific evidence and methodologies about the outcomes, comparative clinical effectiveness, safety, and appropriateness of health care items and services for improving the quality, effectiveness, and efficiency of healthcare.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality

Data Mining Electronic Health Records for Drug Adverse Events

The objective of this project is to use the tree-based scan statistic and Bayesian gamma Poisson shrinkage to search for adverse drug events that are too rare to be detected        during phase three trials by using electronic health records of several million people enrolled in selected insurance plans in the HMO Research Network.
Role: Co-Investigator
Funder: National Institute of Arthritis and Musculoskeletal and Skin Diseases

A Pilot Study for the Identification of Severe Cutaneous Reactions and Genomic Risk Factors in Users of Antiepileptics
In this pilot project we will develop and test a methodology to identify Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) cases hospitalized before 10/2008, test the positive and negative predictive values of the ICD9 codes for SJS and TEN introduced in 10/2008, and estimate the total number of SJS and TEN cases available for either a population-based pharmacogenetic or retrospective epidemiological study of SJS and TEN.
Role: Co-Investigator

Feasibility of Studying Adverse Events Associated with Bisphosphonate Use

In this work, FDA is seeking information on the feasibility of conducting a study to examine the risk of atypical femoral fractures and/or esophageal cancer in osteoporotic   patients on long-term bisphosphonates therapy compared with osteoporotic patients not on bisphosphonate therapy.
Role: Principal Investigator Funder: United States Food and Drug Administration


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Deb Ritzwoller Debra P. Ritzwoller, PhD

Infrastructure Support to Develop the Center for Excellence in Cancer and Genomics (C-Gen)
This project aims to establish a Center for Excellence in Cancer and Genomics (C-Gen) at KPCO.  C-Gen will bring considerable expertise in cancer and genomics into an organized structure that will allow for efficiency, enhanced collaboration and rapid growth in this content area.
Role: Co-Director
Funder: Kaiser Permanente Colorado Strategic initiatives Committee

5ARI and Prostate Cancer Mortality
The objective for KPSC in this proposal is to collaborate with GlaxoSmithKline and Kaiser Permanente Northern California (KPNC), Northwest (KPNW) and Colorado (KPCO) on a project investigating whether the treatment of lower urinary tract symptoms is associated with prostate cancer mortality. Specifically, this study will assess and compare prostate cancer mortality among men being treated with alpha-blockers (AB), 5-alpha reductase inhibitors (5ARI) or combination therapy.
Role: Co-Investigator
Funder: KPCO Glaxo Smith Kline

Cancer Recurrence: Detection in Administrative Data, Incidence, and Costs
The goal of this project is to promising two-phase probabilistic model that first determines the probability of recurrence and then estimates the date on which it occurred. We are now building on this work, conducting further development and validation of the algorithm, and then applying it to generate policy-relevant data on the public health burden imposed by recurrent advanced cancer.
Role: Principal Investigator
Funder: National Cancer Institute

Commonly Used Medications and Risk of Colorectal Cancer Recurrence
This application seeks to evaluate the influence of commonly used medications on colorectal cancer recurrence. This will be achieved through a retrospective cohort study in two population-based integrated healthcare delivery systems within the Cancer Research Network (CRN) with its shared Virtual Data Warehouse. Using the NCI's Surveillance, Epidemiology and End Results (SEER) registry and Kaiser's tumor registry, we will identify approximately 3300 incident stage I-IIIA colorectal cancers diagnosed from 1995-2014. Cancer recurrence – which is not collected in the tumor registries – will be ascertained from targeted medical chart review.
Role: Co-Investigator
Funder: National Cancer Institute

CESR PSA Directed Query
The goal of this study is to employ a large, multi-regional, well-designed case-control study in order to evaluate the effect of these types of biases and determine how using different methodologic approaches affect the association between PSA and prostate cancer mortality.
Role: Site Investigator
Funder: CESR


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Deb Ritzwoller Emily B. Schroeder, MD, PHD

Multi-Institutional Consortium for CER in Diabetes Treatment and Prevention (PROSPECT; SUPREME-DM)
This "next-generation" multi-system registry is intended to serve as a resource for a wide range of CER on both individual therapies and system-level   interventions, and specifically to support examination of heterogeneity in effectiveness across patient subgroups defined by race/ethnicity, age, co-morbidities, or psychosocial variables, and across systems.
Funder: Agency for Healthcare Research and Quality

Applying National Guidelines for Defining CKD in Clinical Data: A DataLink Substudy of SUPREME-DM

This pilot substudy of the SUPREME-DM study investigates the impact of national guidelines for defining CKD, when applied to clinical data, on sensitivity, specificity, and missing data.
Funder: Agency for Healthcare Research and Quality


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John Steiner John F. Steiner, MD, MPH

Multi-institutional Consortium for CER in Diabetes Treatment and Prevention
Role: Principal Investigator
Funder:  Agency for Healthcare Research and Quality 

Scalable Partnering Network for CER: Across Lifespan, Conditions and Settings

The objective is to develop a distributed research network that is interoperable across a range of health care systems and sites, incorporating large and diverse patient populations.  The network infrastructure will have the capability to conduct large comparative effectiveness research (CER) studies using data collected on patient-reported outcomes collected at the point of care and real-time data collection.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality
 
Health Outcomes for Complex Patients: Continuity of Care and Patient Perspectives
Assess health outcomes in complex patients as a function of multiple different subjective factors such mediated by different types of continuity of care.
Role: Co-Investigator
Funder: Agency for Healthcare Research and Quality


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Stanley Xu Stanley Xu, PhD

Vaccine Safety Datalink: Comprehensive Link Data Collection of Medical Events and Immunization
To investigate the safety of vaccines in children and adults in a large national cohort
Role: Co-Investigator/Biostatistician
Funder: Centers for Disease Control and Prevention/ America’s Health Insurance Plans

Telecommunications Enhanced Asthma Management (TEAM)
This project is a practical, randomized clinical trial to test the impact of a health communication intervention designed to improve inhaled asthma controller medication adherence in 3-12 year old children with asthma through parental contact.
Role: Biostatistician
Funder: National Heart Lung and Blood Institute

Colorado Clinical and Translational Sciences Institute (CCTSI), the Biostatistics, Epidemiology, and Research Design (BERD) Program
Goals of the Biostatistics, Epidemiology, and Research Design (BERD) Program are 1) Develop and maintain the BERD leadership and biostatistics consortium; 2) Provide consultation/collaboration in biostatistics, epidemiology, and study design; 3) Provide training and mentorship in biostatistics and epidemiology; 4) To advance biostatistical and epidemiological methods for translational research.
Role: Biostatistician/Steering committee of BERD core
Funder: National Institutes of Health/ National Center for Research Resources

Longitudinal Studies of Implantable Cardiac Defibrillators (ICDs)
The overall objective of this modified study is to gain understanding of the patterns and appropriateness of device therapies among patients undergoing ICD implantation for primary prevention of sudden cardiac death.
Role: Lead Biostatistician
Funder: National Institutes of Health/ Agency for Healthcare Research and Quality


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