An update on the Epidemiology, Molecular Characterization, Diagnosis, and Screening Strategies for Early-Onset Colorectal Cancer.

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Burnett-Hartman AN, Lee JK, Demb J, Gupta S. An update on the epidemiology, molecular characterization, diagnosis, and screening strategies for early-onset colorectal cancer. Gastroenterology. 2021 Jan 5:S0016-5085(21)00008-1. doi: 10.1053/j.gastro.2020.12.068. Epub ahead of print. PMID: 33417940.

Conclusion:

Rising trends in the incidence and mortality of early-onset colorectal cancer (CRC) in those who are ages less than 50 years have been well-established. These trends have spurred intense investigation focused on elucidating the epidemiology and characteristics of early-onset CRC, as well on identifying strategies for early detection and prevention. In this review, we provide a contemporary update on early-onset CRC with a particular focus on epidemiology, molecular characterization, red flag signs and symptoms, and screening for early-onset CRC.

Restrictive Opioid Prescribing Policies and Evolving Risk Environments: A Qualitative Study of the Perspectives of Patients who Experienced an Accidental Opioid Overdose.

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Mueller SR, Glanz JM, Nguyen AP, Stowell M, Koester S, Rinehart DJ, Binswanger IA. Restrictive opioid prescribing policies and evolving risk environments: A qualitative study of the perspectives of patients who experienced an accidental opioid overdose. Int J Drug Policy. 2021 Jan 7:103077. doi: 10.1016/j.drugpo.2020.103077. Epub ahead of print. PMID: 33423916.

Conclusion:

For some patients, macro-level policies and guidelines designed to reduce opioid overdoses by restricting opioid supply may have paradoxically created a micro-level risk environment that contributed to overdose events in a subset of patients.