Matthew F. Daley, MD

Senior Clinician Investigator

Matthew F. Daley, MD, is a Senior Clinician Investigator at the Institute for Health Research. He conducts research on a broad range of pediatric-oriented topics. He is focused particularly on vaccine-related topics, including vaccine safety, vaccination coverage, and parental vaccine hesitancy. For many years, he has also worked to expand the use of multi-institutional electronic health record data for public health surveillance and research purposes.

Dr. Daley received his medical training at Stanford University School of Medicine and completed a residency and chief residency in Pediatrics at the University of Colorado.

Dr. Daley is a practicing pediatrician at Kaiser Permanente Colorado, and an Associate Professor in the Department of Pediatrics at the University of Colorado School of Medicine. He is a Fellow in the American Academy of Pediatrics and a member of the Academic Pediatrics Association. He is currently a member of the Advisory Committee on Immunization Practices (ACIP), which provides advice and guidance to the Centers for Disease Control and Prevention (CDC) on the use of vaccines in the U.S. civilian population.

Selected Research:

  • Vaccine Safety Datalink Project
  • The goal of this project is to evaluate the safety of currently licensed (or authorized for emergency use) vaccines in the United States. To accomplish this, we lead specific vaccine safety studies, and use privacy-protecting approaches to contribute electronic health record data to multiple vaccine safety investigations.

    • Funder: Centers for Disease Control and Prevention
    • Award End Date: 09/27/2027

  • Vaccine Safety Datalink, VSD COVID-19 Infrastructure
  • The goal of this project is to contribute broadly to US efforts to monitor the safety and effectiveness of SARS-CoV-2 vaccines.

    • Funder: Centers for Disease Control and Prevention
    • Award End Date: 09/27/2027

  • Population-level Assessment of Early Childhood Vaccination Timeliness
  • The goal of this project is to use annual National Immunization Survey-Child data to examine patterns and trends of childhood vaccination patterns across the United States. By better understanding vaccination patterns, we aim to distinguish children under-vaccinated due to vaccination access barriers from those under-vaccinated due to parental vaccine hesitancy. We also seek to determine whether trends in schedule adherence or completion of vaccine series are modified by rurality.

    • Funder: National Institutes of Health
    • Award End Date: 08/31/2025

  • Medications and Weight Gain in PCORnet: The MedWeight Study
  • The objective of this study is to determine the comparative effects of initiating and continuing treatment with commonly used medications on weight gain and other metabolic outcomes up to 10.5 years after initiation, among children and adults.

    • Funder: National Institutes of Health/NIDDK
    • Award End Date: 01/31/2024